Your Mac provides several tools to help you identify it. The simplest is About This Mac, available by choosing About This Mac from the Apple menu in the upper-left corner of your screen. The other is the System Information app. Learn how to use these tools to identify your Mac.
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Breast cancer is a complex and heterogeneous disease: Several molecular alterations cause cell proliferation and the acquisition of an invasive phenotype. Extracellular matrix (ECM) is considered essential for sustaining tumor growth and matrix metalloproteinases (MMPs) have been identified as drivers of many aspects of the tumor phenotype. Mounting evidence indicates that both α-enolase (ENO1) and Myc promoter-binding protein-1 (MBP-1) also played pivotal roles in tumorigenesis, although as antagonists. ENO1 is involved in cell growth, hypoxia tolerance and autoimmune activities besides its major role in the glycolysis pathway. On the contrary, MBP-1, an alternative product of ENO1, suppresses cell proliferation and the invasive ability of cancer cells. Since an important task in personalized medicine is to discriminate a different subtype of patients with different clinical outcomes including chances of recurrence and metastasis, we investigated the functional relationship between ENO1/MBP-1 expression and MMP-2 and MMP-9 activity levels in both tissues and sera of breast cancer patients. We focused on the clinical relevance of ENO1 and MMPs (MMP-2 and MMP-9) overexpression in breast cancer tissues: The association between the higher ENO1, MMP-2 and MMP-9 expression with a worse prognosis suggest that the elevated ENO1 and MMPs expression are promising biomarkers for breast cancer. A relationship seems to exist between MBP-1 expression and the decrease in the activity levels of MMP-9 in cancer tissues and MMP-2 in sera. Moreover, the sera of breast cancer patients grouped for MBP-1 expression differentially induced, in vitro, cell proliferation and migration. Our findings support the hypothesis of patient's stratification based on ENO1, MBP-1 and MMPs expression. Elucidating the molecular pathways through which MBP-1 influences MMPs expression and breast cancer regression can lead to the discovery of new management strategies.
I bought a MacBook Pro 9,1 (Mid 2012, 15inch, NOT retina). Can anyone tell me how to install Ubuntu 12.04 on it I already have Windows installed via BootCamp. Also, where to install drivers for Ubuntu and all This link has nothing for 9,1 so please help me. If I have to remove BootCamp and reinstall Windows manually because BootCamp doesn't allow resizing of partitions, that's fine. Please tell me how to install Precise on MBP 9,1
My suggestion is to just install it on a flash drive and before it shows the apple boot logo, hold option key and select the flash drive. It performs surprisingly fast off a flash drive. I have a cousin that uses this method on his Mac.
I have one of these and have still not got it all working properly. However I have managed to get Mint 13 (derived from 12.04) installed on it. The basic setup that you are asking about is described here. In order to get an Ubuntu live image to boot you need to pass some options to the kernel as described here in the section entitled 3rd attempt. I could only get it to boot from a DVD, it wouldn't work from a USB drive for me.
Install 12.10 -use the 64 bit version on the default download page -it has EFI boot support ie: ubuntu-12.10-desktop-amd64+mac.iso.-Download and install Refind on your macbook pro.-Hold down Option key during booting the macbook pro and insert the DVD/CD. Wait for it to be read and select \"EFI Boot\" NOT \"Windows\"
Upgrade To 13.04 (Its Pretty Stable For Me :) using for Java development)-Install and update your 12.10 completely.-Once 12.10 is installed and updated, upgrade to 13.04 using: sudo do-release-upgrade -d[it should now download the 13.04 packages and upgrade. Everything worked for me out of the box except my wireless]
I have a non retina macbook pro 9,1 as well. I followed the installation instructions for a mbp on the ubuntu website (with refit), but after the installation would complete, I'd reboot, and after passing the grub screen, get an unresponsive black screen.
The solution I found to get a good install is to remove all nvidia drivers after installation and before reboot, via sudo apt-get remove --purge nvidia-*. I don't know exactly why this worked for me, but it did.
To give a little bit of backstory: I had macOS and Arch dual-booting on my machine for a year or so now and after an update, Arch stopped working (vmlinuz-linux timed out). Tried looking into the drive from macOS, but macOS didn't start too (displayed a prohibitory sign on startup). I felt that fixing this issue would take a loong time and I'd be better off just installing Ubuntu for now. Huh.
So I installed Ubuntu 17.10 via a USB stick, following Canonical tutorials like this one. Needless to say, my computer did not boot, showing a flashing folder with a question mark instead (after showing a white screen for about 30 seconds - normally it only needs about 10 seconds to boot). People say this means that the computer does not know where to boot from. I looked into the interwebs and found different suggestions:
Also, just to add confusion: The computer did successfully boot into Debian and Ubuntu once and then never again. Couldn't reproduce anything (what I tried was resetting the NVRAM and entering recovery mode to select my hard drive as start disk).
From the output of the sudo fdisk -l /dev/sda command, determine the device for the EFI System partition. For me, this was /dev/sda1. If you determine a different device, make the appropriate substitutions.
I spent 9 years waiting to buy the new MacBook Pro. Literally. I didn't know this model was coming out this year, but I waited since 2012's first Retina Display MacBook Pro to upgrade to a newer, faster model. But since I waited that long, I had a difficult series of choices to make about configuring my new MacBook Pro. Because while it's one of the best MacBooks in years (and one of the best laptops overall), it's a laptop that comes with a lot of choices.
But then I started to look at the numbers. My 15-inch MacBook Pro's display measured 2880x1800 pixels, with a density of 220 pixels per inch, and the 14-inch MacBook Pro (3024x1964 pixels, 254ppi) has both more real-estate and is sharper to boot.
Also, our testing showed that these panels are similar enough on sRGB color output (14-inch: 109.6%, 16-inch: 109.3%) and brightness (14-inch: 487.8 nits, 16-inch: 500.6 nits), so I had nothing to really lose by going smaller. Battery life (14-inch: 14:08, 16-inch: 15:31) is also similar enough.
But then I got the 14-inch model in my hands for my review. Holding it, I knew pretty quickly that I wouldn't want a larger chassis. This was the juuuuust right Goldilocks option, and the easiest call of the bunch.
This decision is also made easier by the face that neither model has more or less ports. Both feature MagSafe 3 charging, HDMI-out, three Thunderbolt 4/USB4 ports, a headphone jack and an SD memory reader.
I know, for a fact, that I don't need that turbo-charged M1 Max power. The first sign of this was when Apple said M1 Max systems could extend their displays to up to 4 displays at once (up to three of 6K displays plus one 4K panel), while the M1 Pro could merely connect to up to two 6K displays. As someone who only needs to connect to one monitor at a time at the most, I knew the Pro would be closer to what I needed.
Then, then came the benchmarks. In my review, I compared the 10-core M1 Pro-powered 14-inch MacBook Pro to a 10-core M1 Max-based 16-inch MacBook Pro, and found that they often had similar (or similar enough) scores. That happened with the multi-core Geekbench 5 scores (M1 Pro: 12,477, M1 Max: 12,683) and our Handbrake video transcoding test (M1 Pro: 4:51, M1 Max: 4:48, where lesser is better) and the PugetBench Photoshop test (M1 Pro: 806, 4:54, M1 Max: 877, 4:44).
Graphics tests saw the M1 Max win out, though. On the 3DMark Wild Life Extreme Unlimited test, the M1 Pro took home a score of 10,386 at 62.17 frames per second, behind the M1 Max's 20,220 score at 121 frames per second. Also, the M1 Max ran Rise of the Tomb Raider at 74fps, much faster than the 39fps rate of the M1 Pro.
All of this had me leaning toward M1 Pro, as I do not plan to push this MacBook Pro to its graphical extremes. I want something future-proof, sure, but I also don't want to overpay for power I'll never use. The most graphics-related work I'll wind up working with (at least from where I see myself at the moment), with some video editing where I take live-streams from my Twitch channel or videos I shoot on my phone, and chop them up into something more easily digestible.
And so the M1 Max is definitely too much for me. Just look at how Apple (opens in new tab) describes the M1 Max's purpose, noting it's \"designed for graphics-intensive workflows like multicam video editing or rendering complex 3D scenes,\" and that its \"powerful media engine lets you play back up to 5 streams of 8K ProRes 422 video.\"
That just left me one real topic to drill down to: which M1 Pro chip is right for me There are three M1 Pro variants available: one with an 8-core CPU and 14-core GPU, $200 more gets you a 10-core CPU and 14-core GPU M1 Pro and then there's the high-end M1 Pro ($300 more), with a 10-core GPU and 16-core GPU. All versions have the same 16-core Neural Engine.
Memory is an interesting thing. On my 15-inch MacBook Pro I had 16GB of RAM, which often felt okay. And it's the kind of thing where 16GB, the starting amount on the 14-inch MacBook Pro, could probably be enough.
But I don't really want enough for this MacBook Pro. I don't really want to need to close browser windows if I don't feel like it. I want to be able to have all of the Chrome and Safari tabs open, if I so choose. 59ce067264